Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biologic Response of Human Intervertebral Disc Cells to Gene Therapy Cocktail

1 Aug 2008

Abstract excerpt

In Brief Study Design. In vitro experiment using human intervertebral disc (IVD) cells and adenovirus-therapeutic gene constructs. Objective. To examine the biologic effect of “cocktail” therapeutic gene transfer to human IVD cells in three-dimensional cultures. Summary of Background Data. Gene therapy is regarded as a potential option for the treatment of degenerative disc disease. Although various anabolic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Spine and Intervertebral Disc Pathology
Share to Tendon Structure and Treatment
Share to Veterinary Orthopedics and Neurology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18622355
DOI: 10.1097/brs.0b013e31817e1cd7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biologic Response of Human Intervertebral Disc Cells to Gene Therapy CocktailPMID 18622355Read ↗

Gene Therapy Approaches for Intervertebral Disc DegenerationSemantic proximity Read ↗

A Review of Gene Therapy Delivery Systems for Intervertebral Disc DegenerationSemantic proximity Read ↗

1999 Volvo Award Winner in Basic Science StudiesSemantic proximity Read ↗

Human Intervertebral Disc Cells Are Genetically Modifiable by Adenovirus-Mediated Gene TransferSemantic proximity Read ↗

Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor gene transferSemantic proximity Read ↗

Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cellsSemantic proximity Read ↗

A single versus multi-vector approach to treating post-traumatic osteoarthritis using scAAV2 IL-1ra or scAAV2 IL-1ra/IGF-I in an equine preclinical modelSemantic proximity Read ↗

Development of a two-step protocol for culture expansion of human annulus fibrosus cells with TGF-β1 and FGF-2Semantic proximity Read ↗

Acceleration of articular cartilage repair by combined gene transfer of human insulin-like growth factor I and fibroblast growth factor-2 in vivoSemantic proximity Read ↗

Nonviral Gene Delivery of Growth and Differentiation Factor 5 to Human Mesenchymal Stem Cells Injected into a 3D Bovine Intervertebral Disc Organ Culture SystemSemantic proximity Read ↗

Adeno-Associated Vector mediated gene transfer of Transforming Growth Factor -beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolismSemantic proximity Read ↗

Effect of adenovirus-mediated TGF-β1 gene transfer on the function of rabbit articular chondrocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.