Article
Bone marrow stromal cells spontaneously produce Flt3-ligand: influence of ionizing radiations and cytokine stimulation.
International journal of radiation biology - 1 Aug 2008
Bertho Jean Marc, Demarquay Christelle, Mouiseddine Moubarak, Douenat Noémie, Stefani Johanna, Prat Marie, Paquet François
Abstract excerpt
PURPOSE: To define the ability of human bone marrow (BM) stromal cells to produce fms-like tyrosine kinase 3 (Flt3)-ligand (FL), and the effect of irradiation, tumour necrosis factor-alpha (TNFalpha) or tumour growth factor beta (TGFbeta) on FL production. MATERIAL AND METHODS: Primary BM stromal cell cultures were irradiated at 2-10 Gy or were stimulated with TNFalpha or TGFbeta1. The presence of FL was tested...
Topics
- Bone Marrow Cells
- Cell Differentiation
- Cells, Cultured
- Humans
- Membrane Proteins
- Osteoblasts
- Phenotype
- Stromal Cells
- Transforming Growth Factor beta1
- Tumor Necrosis Factor-alpha
