Article
Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE.
BMC medical genetics - 7 Jul 2008
D'souza Anil, Kurien Biji T, Rodgers Rosalie, Shenoi Jaideep, Kurono Sadamu, Matsumoto Hiroyuki, Hensley Kenneth, Nath Swapan K, Scofield R Hal
Abstract excerpt
BACKGROUND: Systemic lupus erythematosus (SLE) is a multifactorial disorder characterized by the presence of autoantibodies. We and others have implicated free radical mediated peroxidative damage in the pathogenesis of SLE. Since harmful free radical products are formed during this oxidative process, including 4-hydroxy 2-nonenol (4-HNE) and malondialdehyde (MDA), we hypothesized that specific HNE-protein...
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