Article
ABL single nucleotide polymorphisms may masquerade as BCR-ABL mutations associated with resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia.
Haematologica - 1 Sept 2008
Ernst Thomas, Hoffmann Jana, Erben Philipp, Hanfstein Benjamin, Leitner Armin, Hehlmann Rüdiger, Hochhaus Andreas, Müller Martin C
Abstract excerpt
The BCR-ABL K247R change is based on a rare single nucleotide polymorphism occurring likewise in healthy controls and non-hematologic cell types. Despite its juxtaposition to the P-loop, functional analysis showed no alteration compared to non-mutated BCR-ABL. We sought to investigate if other changes in the BCR-ABL kinase domain should be considered as single nucleotide polymorphisms rather than acquired...
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