Article
Sustained delayed-type hypersensitivity reaction after in vivo priming but successful induction of unresponsiveness after adoptive transfer of CD4+ effector T cells.
Cellular immunology - 1 Jan 2000
Blumenthal-Barby Friderike, Schrage Arnhild, Eulenburg Katharina, Zeitz Martin, Hamann Alf, Klugewitz Katja
Abstract excerpt
Potential reasons for weak effects of oral tolerance in the primed immune system are still under discussion. In the present study, impacts of oral antigen uptake were studied in adoptive transfer models using T cell receptor transgenic CD4(+) T cells allowing analysis of antigen-specific donor cells on single cell level. After in vivo priming and subsequent feeding, an antigen-specific delayed-type...
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