Article
The crystal structure of the platelet activator aggretin reveals a novel (alphabeta)2 dimeric structure.
Biochemistry - 29 Jul 2008
Hooley Elizabeth, Papagrigoriou Evangelos, Navdaev Alexei, Pandey Amit V, Clemetson Jeannine M, Clemetson Kenneth J, Emsley Jonas
Abstract excerpt
Aggretin is a C-type lectin purified from Calloselasma rhodostoma snake venom. It is a potent activator of platelets, resulting in a collagen-like response by binding and clustering platelet receptor CLEC-2. We present here the crystal structure of aggretin at 1.7 A which reveals a unique tetrameric quaternary structure. The two alphabeta heterodimers are arranged through 2-fold rotational symmetry, resulting in...
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