Article
BRCA1 185delAG truncation protein, BRAt, amplifies caspase-mediated apoptosis in ovarian cells.
In vitro cellular & developmental biology. Animal - 1 Jan 2000
O'Donnell Joshua D, Johnson Nicole C, Turbeville Tracy D, Alfonso Michelle Y, Kruk Patricia A
Abstract excerpt
Breast and ovarian cancer patients with germline mutations in BRCA1 respond more favorably to initial chemotherapy. We previously reported that cells from women carrying the BRCA1 185delAG founder mutation undergo an enhanced caspase-3-mediated apoptotic response. Here, we report on the transient and stable transfection of cDNA coding for the putative truncated protein product of the BRCA1 185delAG mutant gene...
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