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Article

Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.

American journal of human genetics - 1 Jul 2008

Anderson Carl A, Pettersson Fredrik H, Barrett Jeffrey C, Zhuang Joanna J, Ragoussis Jiannis, Cardon Lon R, Morris Andrew P

Abstract excerpt

Genotype imputation is potentially a zero-cost method for bridging gaps in coverage and power between genotyping platforms. Here, we quantify these gains in power and coverage by using 1,376 population controls that are from the 1958 British Birth Cohort and were genotyped by the Wellcome Trust Case-Control Consortium with the Illumina HumanHap 550 and Affymetrix SNP Array 5.0 platforms. Approximately 50% of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18589396
DOI: 10.1016/j.ajhg.2008.06.008
PMCID: PMC2443836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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