Article
Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening.
Journal of nephrology - 1 Jan 2000
Nair Sunita, Phillips Aled O, Norton Nadine, Spurlock Gillian, Williams Hywel J, Craig Kathrine J, Williams John D, Williams Nigel M, Bowen Timothy
Abstract excerpt
BACKGROUND: Diabetic nephropathy is characterised by extracellular matrix (ECM) expansion, a key modulator of which is TGF-b1. Glucose-stimulated transcriptional activation of the TGF-b1 gene is an important component of the pathogenesis of nephropathy, following which latent TGF-b1 protein is sy...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.