Article
K313dup is a recurrent CEBPA mutation in de novo acute myeloid leukemia (AML).
Annals of hematology - 1 Oct 2008
Carnicer Maria J, Lasa Adriana, Buschbeck Marcus, Serrano Elena, Carricondo Maite, Brunet Salut, Aventin Anna, Sierra Jorge, Di Croce Luciano, Nomdedeu Josep F
Abstract excerpt
The CEBPA gene codes for a transcription factor that has a pivotal role in controlling proliferation and differentiation of myeloid progenitors. Acquired CEBPA mutations have been found in acute myeloid leukemias (AML) with a good prognosis, and most of these patients have a normal karyotype. In this paper, we report four cases that displayed the same K313dup in the CEBPA gene. All four had an AML-M1 with CD7...
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