Article
The effects of histone deacetylase inhibitors on the induction of differentiation in chondrosarcoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2007
Sakimura Riku, Tanaka Kazuhiro, Yamamoto Syunsaku, Matsunobu Tomoya, Li Xu, Hanada Masuo, Okada Takamitsu, Nakamura Tomoyuki, Li Yang, Iwamoto Yukihide
Abstract excerpt
PURPOSE: Histologically, chondrosarcomas represent the degree of chondrogenic differentiation, which is associated with the prognosis of the disease. Histone acetylation and deacetylation play key roles in the regulation of chondrocytic differentiation. Here, we describe the antitumor effects of...
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