Article
A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: a community-based approach to understanding the impact.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jul 2008
Arbour Laura, Rezazadeh Saman, Eldstrom Jodene, Weget-Simms Gwen, Rupps Rosemarie, Dyer Zoe, Tibbits Glen, Accili Eric, Casey Brett, Kmetic Andrew, Sanatani Shubhayan, Fedida David
Abstract excerpt
PURPOSE: Hereditary long QT syndrome is named for a prolonged QT interval reflecting predisposition to ventricular arrhythmias and sudden death. A high rate in a remote, northern Canadian First Nations community was brought to attention. METHODS: Two severely affected index cases and 122 relative...
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