Article
Ascl3 expression marks a progenitor population of both acinar and ductal cells in mouse salivary glands.
Developmental biology - 1 Aug 2008
Bullard Tara, Koek Laurie, Roztocil Elisa, Kingsley Paul D, Mirels Lily, Ovitt Catherine E
Abstract excerpt
Ascl3, also know as Sgn1, is a member of the mammalian achaete scute (Mash) gene family of transcription factors, which have been implicated in cell fate specification and differentiation. In the mouse salivary gland, expression of Ascl3 is restricted to a subset of duct cells. Salivary gland function depends on the secretory acinar cells, which are responsible for saliva formation, and duct cells, which modify...
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