Article
Impaired body movement representation in DYT1 mutation carriers.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology - 1 Aug 2008
Fiorio M, Gambarin M, Defazio G, Valente E M, Stanzani C, Moretto G, Loi M, Soliveri P, Nardocci N, Albanese A, Fiaschi A, Tinazzi M
Abstract excerpt
OBJECTIVE: The only known genetic cause of early-onset primary torsion dystonia is the GAG deletion in the DYT1 gene. Due to the reduced penetrance, many mutation carriers remain clinically asymptomatic, despite the presence of subclinical abnormalities, mainly in the motor control circuitry. Our aim was to investigate whether the DYT1 mutation impairs the inner simulation of movements, a fundamental function for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.