Article
Temporal discrimination threshold: VBM evidence for an endophenotype in adult onset primary torsion dystonia.
Brain : a journal of neurology - 1 Sept 2009
Bradley D, Whelan R, Walsh R, Reilly R B, Hutchinson S, Molloy F, Hutchinson M
Abstract excerpt
Familial adult-onset primary torsion dystonia is an autosomal dominant disorder with markedly reduced penetrance. Most adult-onset primary torsion dystonia patients are sporadic cases. Disordered sensory processing is found in adult-onset primary torsion dystonia patients; if also present in their unaffected relatives this abnormality may indicate non-manifesting gene carriage. Temporal discrimination thresholds...
Topics
- Adult
- Aged
- Discrimination, Psychological
- Dystonia Musculorum Deformans
- Heterozygote
- Humans
- Magnetic Resonance Imaging
- Middle Aged
- Pedigree
- Phenotype
- Putamen
- Sensory Thresholds
- Time Perception
- Young Adult