Article
Coinheritance of sickle cell anemia and hereditary spherocytosis.
Pediatric blood & cancer - 1 Oct 2008
Selcuk Duru Nilgun, Celkan Tiraje, Civilibal Mahmut, Ozbek Nur Ozden, Basak A Nazli, Elevli Murat
Abstract excerpt
To date only three siblings with coinheritance of sickle cell anemia (SCA) and hereditary spherocytosis (HS) have been reported. We here describe a 17-year-old boy who experienced episodes of hemolysis and had a large spleen. The diagnosis of SCA was confirmed by hemoglobin electrophoresis (HbS 88.9%) and genetic analysis (homozygote HbSS mutation). The diagnosis of HS was established by an osmotic fragility...
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