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Article

siRNA-mediated reduction of alpha-globin results in phenotypic improvements in beta-thalassemic cells.

Haematologica - 1 Aug 2008

Voon Hsiao Phin Joanna, Wardan Hady, Vadolas Jim

Abstract excerpt

beta-thalassemia is an inherited hemoglobinopathy caused by defective synthesis of the beta-globin chain of hemoglobin, leading to imbalanced globin chain synthesis. Excess alpha-globin precipitates in erythroid progenitor cells resulting in cell death, ineffective erythropoiesis and severe anemi...

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Source

Identifiers

PMID: 18556409
DOI: 10.3324/haematol.12555

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18556409-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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