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Tissue-specific Programming Expression of Glucocorticoid Receptors and 11β-HSDs by Maternal Perinatal Undernutrition in the HPA Axis of Adult Male Rats

31 Mar 2008

Abstract excerpt

Maternal undernutrition leads to intrauterine growth retardation and predisposes to the development of pathologies in adulthood. The hypothalamo-pituitary-adrenal axis is a major target of early-life programming. We showed previously that perinatal maternal 50% food restriction leads to hypothalamo-pituitary-adrenal axis hyperactivity and disturbs glucocorticoid feedback in adult male rats. To try to better...

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PMID: 18548384
DOI: 10.1055/s-2008-1058064

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