Article
The molecular mechanism regulating 24-hour rhythm of CYP2E1 expression in the mouse liver.
Hepatology (Baltimore, Md.) - 1 Jul 2008
Matsunaga Naoya, Ikeda Misaki, Takiguchi Takako, Koyanagi Satoru, Ohdo Shigehiro
Abstract excerpt
UNLABELLED: Cytochrome P450 2E1 (CYP2E1) is clinically and toxicologically important and exhibits 24-hour periodicity in its activity. In the present study, we investigated whether hepatic nuclear factor-1alpha (HNF-1alpha) and clock genes with a striking 24-hour rhythm in mouse liver contributed to the 24-hour regulation of CYP2E1 expression. The results demonstrated that the expression of CYP2E1 messenger RNA...
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