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Imatinib mesylate for the treatment of chronic myeloid leukemia

1 Jun 2008

Abstract excerpt

Chronic myeloid leukemia (CML) is the first human malignancy for which the promise of targeted therapy has come true. CML is invariably associated with a specific genetic lesion--the t(9;22) chromosomal translocation. As a consequence of this translocation, a BCR-ABL fusion gene is formed on the 22q- derivative (traditionally known as the Philadelphia chromosome) and the deregulated tyrosine kinase activity of...

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PMID: 18533795
DOI: 10.1586/14737140.8.6.853

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