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Imatinib Mesylate — The New Gold Standard for Treatment of Chronic Myeloid Leukemia

13 Mar 2003

Abstract excerpt

Chronic myeloid leukemia (CML) is a clonal stem-cell disorder in which the reciprocal translocation t(9;22) generates two novel fusion genes: BCR-ABL on the derivative 22q– (Philadelphia) chromosome, and ABL-BCR on chromosome 9q+. The ABL gene product is a protein tyrosine kinase, and the fusion protein BCR-ABL has constitutive kinase activity that deregulates signal transduction pathways, causing abnormal cell...

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PMID: 12637616
DOI: 10.1056/nejme030009

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