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New and established tyrosine kinase inhibitors for chronic myeloid leukemia

1 Jan 2012

Abstract excerpt

Chronic myeloid leukemia (CML) is an uncommon malignancy, the treatment and prognosis of which have dramatically shifted over the last decade. Characterized by a translocation between chromosomes 9 and 22, known as the Philadelphia chromosome, small-molecule tyrosine kinase inhibitors (TKIs) targeted against the oncogenic BCR-ABL fusion protein have changed this once fatal disease into the model of targeted...

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PMID: 23032801
DOI: 10.1358/dot.2012.48.9.1869590

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