Article
Sialyl lewisx antigen-expressing human CD4+ T and CD8+ T cells as initial immune responders in memory phenotype subsets.
Journal of leukocyte biology - 1 Sept 2008
Zhang Yue, Ohkuri Takayuki, Wakita Daiko, Narita Yoshinori, Chamoto Kenji, Kitamura Hidemitsu, Nishimura Takashi
Abstract excerpt
Cytokine production by memory T cells in secondary immune responses has a critical role in host defenses. Previously, we had demonstrated that a unique antigen composed of sialyl lewis(x) (sLe(x)) was expressed on CD45RO(+) memory-phenotype subsets of human T cells. Here, we found that the sLe(x) antigen was up-regulated on CD45RA(+) naïve human CD4(+) T and CD8(+) T cells by TCR stimulation. In addition, sLe(x)...
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