Article
Reduction in aortic smooth muscle beta-adrenergic responsiveness results in enhanced norepinephrine responsiveness in the Dahl salt-sensitive rat.
Clinical and experimental hypertension. Part A, Theory and practice - 1 Jan 1991
Soltis E E, Katovich M J
Abstract excerpt
In an earlier report we observed alterations in aortic smooth muscle alpha- and beta-adrenergic responsiveness in the Dahl rat. The present study was designed to define the time course of these changes and further characterize the alterations in this model of hypertension. Four-week-old male Dahl salt-sensitive (DS) rats were placed on either a normal (DSN) or high salt diet (8% NaCl; DSH). Aortic smooth muscle...
Topics
- Animals
- Aorta
- Diet
- Genetic Predisposition to Disease
- Hypertension
- Male
- Muscle, Smooth, Vascular
- Norepinephrine
- Rats
- Rats, Mutant Strains
- Receptors, Adrenergic, beta