Article
HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice.
The Journal of clinical investigation - 1 Jun 2008
Hisatomi Toshio, Nakazawa Toru, Noda Kousuke, Almulki Lama, Miyahara Shinsuke, Nakao Shintaro, Ito Yasuhiro, She Haicheng, Kohno Riichiro, Michaud Norman, Ishibashi Tatsuro, Hafezi-Moghadam Ali, Badley Andrew D, Kroemer Guido, Miller Joan W
Abstract excerpt
Neuroprotection can be achieved by preventing apoptotic death of postmitotic cells. Apoptotic death can occur by either a caspase-dependent mechanism, involving cytochrome c, apoptosis protease-activating factor-1 (Apaf-1), and caspase-9, or a caspase-independent mechanism, involving apoptosis-inducing factor (AIF). HIV protease inhibitors (PIs) avert apoptosis in part by preventing mitochondrial outer membrane...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.