Article
Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy.
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir - 1 Mar 2008
Bayrak Fatih, Kömürcü-Bayrak Evrim, Mutlu Bülent, Kahveci Gökhan, Erginel-Unaltuna Nihan
Abstract excerpt
OBJECTIVES: The Irx4 gene is predominantly expressed in cardiac ventricles. It has been demonstrated in animal studies that disruption of the Irx4 gene causes inhibition of chamber-specific expression of myosin heavy chain genes, resulting in abnormal ventricular gene expression and cardiac hyper...
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