Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo.

doi:10.1016/j.atherosclerosis.2008.04.010

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Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo.

Atherosclerosis - 1 Jan 2009

Dasu Mohan R, Riosvelasco Andrea C, Jialal Ishwarlal

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INTRODUCTION: Toll-like receptors play an important role in the innate immune system and are found to be crucial in severe diseases like sepsis, atherosclerosis, and arthritis. TLR2 and TLR4 expression is upregulated in the inflammatory diseases. Angiotensin II in addition to stimulating vasoconstriction also induces an increase in ROS and a proinflammatory phenotype via AT(1)R. Angiotensin II type-1 receptor...

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Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo.

Abstract excerpt

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