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Article

The cornified cell envelope: an important marker of stratum corneum maturation in healthy and dry skin

1 Aug 2003

Abstract excerpt

The cornified cell envelope (CE) formed by transglutaminase-mediated epsilon-(gamma-glutamyl)lysine cross-linking of specialized corneocyte proteins is the most insoluble component of the terminally differentiated keratinocyte. Under normal Nomarski optics, two types of CE are readily distinguishable: an irregularly shaped, readily deformed 'fragile' envelope (CEf), which predominates in the deepest layers of the...

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PMID: 18494897
DOI: 10.1046/j.1467-2494.2003.00175.x

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