Article
A remarkable depletion of both naïve CD4+ and CD8+ with high proportion of memory T cells in an IPEX infant with a FOXP3 mutation in the forkhead domain.
Scandinavian journal of immunology - 1 Jul 2008
Costa-Carvalho B T, de Moraes-Pinto M I, de Almeida L C, de Seixas Alves M T, Maia R P, de Souza R L, Barreto M, Lourenço L, Vicente A M, Coutinho A, Carneiro-Sampaio M
Abstract excerpt
IPEX is a rare X-linked syndrome, with immune dysfunction, polyendocrinopathy and enteropathy. We describe an infant who died at the age of 11 months after developing eczema, severe diarrhoea, diabetes, hypothyroidism, thrombocytopenia and four episodes of septicaemia. Immunophenotyping of periph...
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