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Article

Cytokinesis-blocked micronucleus cytome assay biomarkers identify lung cancer cases amongst smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2008

El-Zein Randa A, Fenech Michael, Lopez Mirtha S, Spitz Margaret R, Etzel Carol J

Abstract excerpt

The multi-endpoint cytokinesis-blocked micronucleus assay is used for assessing chromosome aberrations. We have recently reported that this assay is extremely sensitive to genetic damage caused by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and that the binucleated cells with micronuclei, nucleoplasmic bridges, and nuclear buds in lymphocytes (chromosome damage endpoints...

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Identifiers

PMID: 18483333
DOI: 10.1158/1055-9965.EPI-07-2827
PMCID: PMC2854407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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