Functional analysis of the essential GTP-binding-protein-coding gene cgtA of Vibrio cholerae.

doi:10.1128/JB.02021-07

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Article

Functional analysis of the essential GTP-binding-protein-coding gene cgtA of Vibrio cholerae.

Journal of bacteriology - 1 Jul 2008

Shah Sangita, Das Bhabatosh, Bhadra Rupak K

Abstract excerpt

The cgtA gene, coding for the conserved G protein CgtA, is essential in bacteria. In contrast to a previous report, here we show by using genetic analysis that cgtA is essential in Vibrio cholerae even in a Delta relA background. Depletion of CgtA affected the growth of V. cholerae and rendered the cells highly sensitive to the replication inhibitor hydroxyurea. Overexpression of V. cholerae CgtA caused distinct...

Topics

Bacterial Proteins
Cell Division
Genes, Essential
Hydroxyurea
Microscopy, Electron, Scanning
Monomeric GTP-Binding Proteins
Mutation
Nucleic Acid Synthesis Inhibitors
Vibrio cholerae

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Identifiers

PMID: 18456812
DOI: 10.1128/JB.02021-07
PMCID: PMC2446790

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