Monitoring cytomegalovirus IE‐1 and pp65‐specific CD4⁺ and CD8⁺ T‐cell responses after allogeneic stem cell transplantation may identify patients at risk for recurrent CMV reactivations

Abstract excerpt

We studied the recovery of CMV-specific CD4+ and CD8+ T-cell immunity in 52 recipients of allogeneic stem cell transplantation (SCT). The proportions of IFN-gamma-producing CD4+ and CD8+ T cells upon in vitro activation using peptide pools representing the CMV pp65 and IE-1 proteins were assessed at multiple time points post SCT, and correlated with the occurrence of CMV reactivation. In a retrospective analysis,...

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