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Article

Cognitive discrepancies versus APOE genotype as predictors of cognitive decline in normal-functioning elderly individuals: a longitudinal study.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 May 2008

Fine Eric M, Delis Dean C, Wetter Spencer R, Jacobson Mark W, Jak Amy J, McDonald Carrie R, Braga Jodessa C, Thal Leon J, Salmon David P, Bondi Mark W

Abstract excerpt

OBJECTIVES: Cognitive-discrepancy analysis has been shown to be a useful technique for detecting subtle cognitive deficits in normal-functioning elderly individuals who are genetically at-risk for Alzheimer disease (AD). However, studies that have used cognitive-discrepancy measures to date have used retrospective or cross-sectional designs, and the utility of this approach to predict cognitive decline has not...

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Identifiers

PMID: 18448849
DOI: 10.1097/JGP.0b013e3181629957
PMCID: PMC3050584

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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