The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study.

doi:10.1016/j.ahj.2008.01.019

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Article

The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study.

American heart journal - 1 May 2008

Mitchell Braxton D, McArdle Patrick F, Shen Haiqing, Rampersaud Evadnie, Pollin Toni I, Bielak Lawrence F, Jaquish Cashell, Douglas Julie A, Roy-Gagnon Marie-Hélène, Sack Paul, Naglieri Rosalie, Hines Scott, Horenstein Richard B, Chang Yen-Pei C, Post Wendy, Ryan Kathleen A, Brereton Nga Hong, Pakyz Ruth E, Sorkin John, Damcott Coleen M, O'Connell Jeffrey R, Mangano Charles, Corretti Mary, Vogel Robert, Herzog William, Weir Matthew R, Peyser Patricia A, Shuldiner Alan R

Abstract excerpt

BACKGROUND: The etiology of cardiovascular disease (CVD) is multifactorial. Efforts to identify genes influencing CVD risk have met with limited success to date, likely because of the small effect sizes of common CVD risk alleles and the presence of gene by gene and gene by environment interactio...

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PMID: 18440328
DOI: 10.1016/j.ahj.2008.01.019
PMCID: PMC2443415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18440328-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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