Article
Spontaneous transposition of IS1096 or ISMsm3 leads to glycopeptidolipid overproduction and affects surface properties in Mycobacterium smegmatis.
Tuberculosis (Edinburgh, Scotland) - 1 Sept 2008
Kocíncová Dana, Singh Anil Kumar, Beretti Jean-Luc, Ren Huiping, Euphrasie Daniel, Liu Jun, Daffé Mamadou, Etienne Gilles, Reyrat Jean-Marc
Abstract excerpt
Natural modification of the colony appearance is a phenomenon that has not been fully understood in mycobacteria. Here, we show that Mycobacterium smegmatis ATCC607 displays a low-frequency spontaneous morphological variation that correlates with the acquisition of a panel of new phenotypes, such as aggregation, biofilm formation and sliding motility. These variants produce larger amounts of glycopeptidolipid...
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