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Article

Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2008

Csiszar Anna, Labinskyy Nazar, Podlutsky Andrej, Kaminski Pawel M, Wolin Michael S, Zhang Cuihua, Mukhopadhyay Partha, Pacher Pal, Hu Furong, de Cabo Rafael, Ballabh Praveen, Ungvari Zoltan

Abstract excerpt

The dietary polyphenolic compound resveratrol, by activating the protein deacetylase enzyme silent information regulator 2/sirtuin 1 (SIRT1), prolongs life span in evolutionarily distant organisms and may mimic the cytoprotective effects of dietary restriction. The present study was designed to elucidate the effects of resveratrol on cigarette smoke-induced vascular oxidative stress and inflammation, which is a...

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Identifiers

PMID: 18424637
DOI: 10.1152/ajpheart.00235.2008
PMCID: PMC2551743

Genes

SIRT1
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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