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Article

Testosterone-inducible regulator is a kinase that drives steroid sensing and metabolism in Comamonas testosteroni.

The Journal of biological chemistry - 20 Jun 2008

Göhler André, Xiong Guangming, Paulsen Simone, Trentmann Gabriele, Maser Edmund

Abstract excerpt

The mechanism of gene regulation by steroids in bacteria is still a mystery. We use steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase (3alpha-HSD/CR) as a reporter system to study steroid signaling in Comamonas testosteroni. In previous investigations we cloned and characterized the 3alpha-HSD/CR-encoding gene, hsdA. In addition, we identified two negative regulator genes (repA and repB) in...

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Identifiers

PMID: 18424443
DOI: 10.1074/jbc.M710166200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Testosterone-inducible regulator is a kinase that drives steroid sensing and metabolism in Comamonas testosteroni.PMID 18424443Read ↗

Regulation of the steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase gene in Comamonas testosteroni.Semantic proximity Read ↗

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Oligomerization and negative autoregulation of the LysR-type transcriptional regulator HsdR from Comamonas testosteroni.Semantic proximity Read ↗

Characterization of 3,17β-hydroxysteroid dehydrogenase in Comamonas testosteroni.Semantic proximity Read ↗

Steroid degradation gene cluster of Comamonas testosteroni consisting of 18 putative genes from meta-cleavage enzyme gene tesB to regulator gene tesR.Semantic proximity Read ↗

A novel transcriptional repressor PhaR for the steroid-inducible expression of the 3,17β-hydroxysteroid dehydrogenase gene in Comamonas testosteroni ATCC11996.Semantic proximity Read ↗

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Identification of a novel steroid inducible gene associated with the beta hsd locus of Comamonas testosteroni.Semantic proximity Read ↗

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