Article
Variant CD44 expression by human fibroblasts.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 May 2008
Rajarajan Abirami, Bloor Balvinder K, Desai Hemini, Stokes Angela, Odell Edward W
Abstract excerpt
CD44 is a cell surface glycoprotein with roles in tumour invasion and metastasis. CD44 is variably spliced from ten variant exons and mis-splicing is a biomarker for detection of colon, urothelial and other carcinomas. Fibroblasts are normally considered to lack variant exons and thus should not generate false-positive signals. Transcription of variant exons by fibroblasts was investigated by exon-specific...
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