Article
T cells that are autoreactive to beta2-glycoprotein I in patients with antiphospholipid syndrome and healthy individuals.
Arthritis and rheumatism - 1 Jan 2000
Hattori N, Kuwana M, Kaburaki J, Mimori T, Ikeda Y, Kawakami Y
Abstract excerpt
OBJECTIVE: To identify the T cells responsive to beta2-glycoprotein I (beta2GPI) that mediate antiphospholipid antibody production in patients with antiphospholipid syndrome (APS). METHODS: In vitro proliferative responses and anti-beta2GPI antibody production induced by beta2GPI were examined in peripheral blood mononuclear cell (PBMC) cultures from 12 APS patients, 13 systemic lupus erythematosus patients...
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