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Article

Looking chloride channels straight in the eye: bestrophins, lipofuscinosis, and retinal degeneration.

Physiology (Bethesda, Md.) - 1 Oct 2005

Hartzell Criss, Qu Zhiqiang, Putzier Ilva, Artinian Liana, Chien Li-Ting, Cui Yuanyuan

Abstract excerpt

Recent evidence suggests that Cl(-) ion channels are important for retinal integrity. Bestrophin Cl(-) channel mutations in humans are genetically linked to a juvenile form of macular degeneration, and disruption of some ClC Cl(-) channels in mice leads to retinal degeneration. In both cases, acc...

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Identifiers

PMID: 16174869
DOI: 10.1152/physiol.00021.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16174869-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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