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XRCC1 polymorphisms and severe toxicity in lung cancer patients treated with cisplatin-based chemotherapy in Chinese population.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2008

Wang Zhonghua, Xu Binghe, Lin Dongxin, Tan Wen, Leaw Shiangjiin, Hong Xiaonan, Hu Xichun

Abstract excerpt

Cisplatin kills tumor cells through DNA cross linking. Alterations in the function of DNA repair genes may affect DNA repair proficiency and influence cancer patients' response to cisplatin. The predictability of DNA repair XRCC1 (X-ray repair cross-complementing group 1 protein) single nucleotide polymorphisms (SNPs) for cisplatin-based grades 3 and 4 chemotherapy-related toxicity in patients with newly...

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Source

Identifiers

PMID: 18400332
DOI: 10.1016/j.lungcan.2008.02.019

Genes

XRCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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