Article
Early onset of polyglandular failure is associated with HLA-DRB1*03.
European journal of endocrinology - 1 Jul 2008
Dittmar Manuela, Ide Maximilian, Wurm Michael, Kahaly George J
Abstract excerpt
OBJECTIVES: Polyglandular failure or autoimmunity (PGA) involves at least two endocrine diseases. Several genes may play a role in its etiology. This study analyzed 1) whether HLA-DRB1, HLA-DQB1, and MHC class I chain-related gene A (MICA) polymorphisms are associated in PGA and 2) whether PGA patients display stronger associations with these immune genes than patients with monoglandular autoimmunity (MGA)....
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