Article
Cascade genetic testing for mismatch repair gene mutations.
Familial cancer - 1 Jan 2008
Mitchell R J, Ferguson R K, Macdonald A, Dunlop M G, Campbell H, Porteous M E
Abstract excerpt
Mismatch repair gene mutation carriers have a high risk of developing colorectal cancer, and can benefit from appropriate surveillance. A combined population based ascertainment cascade genetic testing approach provides a systematic and potentially effective strategy for identifying such carriers. We have developed a Markov Chain computer model system which simulates various factors influencing cascade genetic...
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