Article
High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss.
Genes, chromosomes & cancer - 1 Jul 2008
Kulke Matthew H, Freed Ellen, Chiang Derek Y, Philips Juliet, Zahrieh David, Glickman Jonathan N, Shivdasani Ramesh A
Abstract excerpt
Carcinoid tumors of the small intestine are characterized by an indolent clinical course, secretion of neuropeptides, and resistance to standard cytotoxic chemotherapy. To evaluate the molecular events underlying carcinoid tumorigenesis, we used high-resolution arrays of single nucleotide polymorphisms to study chromosomal gains and losses in 24 primary and metastatic small bowel carcinoid tumors derived from 18...
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