Article
Antibody therapy for chronic lymphocytic leukemia.
Seminars in hematology - 1 Apr 2008
Christian Beth A, Lin Thomas S
Abstract excerpt
The introduction of the monoclonal antibodies rituximab (anti-CD20) and alemtuzumab (anti-CD52) has revolutionized the treatment of chronic lymphocytic leukemia (CLL). Both antibodies were first studied as single agents in relapsed CLL, but rituximab is increasingly used in combination chemoimmunotherapy regimens in previously untreated patients. Phase II studies demonstrated that the addition of rituximab to...
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