Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

31 Mar 2008

Abstract excerpt

Recent evidence demonstrates that senescence acts as a barrier to tumorigenesis in response to oncogene activation. Using a mouse model of breast cancer, we tested the importance of the senescence response in solid cancer and identified genetic pathways regulating this response. Mammary expression of activated Ras led to the formation of senescent cellular foci in a majority of mice. Deletion of the p19(ARF),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to NF-κB Signaling Pathways
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18378907
DOI: 10.1073/pnas.0801505105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence responsePMID 18378907Read ↗

Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4aSemantic proximity Read ↗

BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21Semantic proximity Read ↗

Effects of p21 <sup>Waf1/Cip1/Sdi1</sup> on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseasesSemantic proximity Read ↗

p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and RbSemantic proximity Read ↗

Normal cellular senescence and cancer susceptibility in mice genetically deficient in Ras-induced senescence-1 (Ris1).Semantic proximity Read ↗

p16INK4asuppresses BRCA1-deficient mammary tumorigenesisSemantic proximity Read ↗

RASSF1A Mediates p21Cip1/Waf1-Dependent Cell Cycle Arrest and Senescence through Modulation of the Raf-MEK-ERK Pathway and Inhibition of AktSemantic proximity Read ↗

Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14 <sup>ARF</sup> Tumor SuppressorSemantic proximity Read ↗

Overexpression of the p21 sdi1 gene induces senescence-like state in human cancer cells: implication for senescence-directed molecular therapy for cancerSemantic proximity Read ↗

Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis.Semantic proximity Read ↗

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.Semantic proximity Read ↗

Cyclin D1 Activity Regulates Autophagy and Senescence in the Mammary EpitheliumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.