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Article

Clinical and genetic investigation of atrial septal defect with atrioventricular conduction defect in a large consanguineous Tunisian family.

Archives of medical research - 1 May 2008

Nouira Sonia, Kamoun Ikram, Ouragini Houyem, Charfeddine Cherine, Mahjoub Haifa, Ouechtati Farah, Bchetnia Mbarka, Ben Halima Afef, Abdelhak Sonia, Kachboura Salem

Abstract excerpt

BACKGROUND: Atrial septal defect (ASD) is an autosomal dominant disease characterized by left-to-right shunting and increased right ventricular output. Approximately 5-10% of congenital heart diseases (CHD) are due to ASD, which is one of the most frequent CHD found in adults. The gene responsible for ASD was mapped to chromosome 5q35 encoding the transcription factor NKX2-5 that plays an important role for the...

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Arrhythmias, Cardiac
Consanguinity
Echocardiography
Electrocardiography
Heart Septal Defects, Atrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homeobox Protein Nkx-2.5

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PMID: 18375255
DOI: 10.1016/j.arcmed.2008.01.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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