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The c.156_157insAlu BRCA2 rearrangement accounts for more than one-fourth of deleterious BRCA mutations in northern/central Portugal.

Breast cancer research and treatment - 1 Mar 2009

Peixoto Ana, Santos Catarina, Rocha Patrícia, Pinheiro Manuela, Príncipe Sofia, Pereira Deolinda, Rodrigues Helena, Castro Fernando, Abreu Joaquim, Gusmão Leonor, Amorim António, Teixeira Manuel R

Abstract excerpt

We evaluated the contribution of an Alu insertion in BRCA2 exon 3 (c.156_157insAlu) to inherited predisposition to breast/ovarian cancer in 208 families originated mostly from northern/central Portugal. We identified the c.156_157insAlu BRCA2 mutation in 14 families and showed that it accounts for more that one-fourth of deleterious BRCA1/BRCA2 mutations in breast/ovarian cancer families originated from this part...

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Identifiers

PMID: 18363094
DOI: 10.1007/s10549-008-9978-4

Genes

BRCA2
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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