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Article

Curcumin downregulates H19 gene transcription in tumor cells.

Journal of cellular biochemistry - 1 Aug 2008

Novak Kujundzić Renata, Grbesa Ivana, Ivkić Mirko, Katdare Meena, Gall-Troselj Koraljka

Abstract excerpt

Curcumin (diferuloymethane), a natural compound used in traditional medicine, exerts an antiproliferative effect on various tumor cell lines by an incompletely understood mechanism. It has been shown that low doses of curcumin downregulate DNA topoisomerase II alpha (TOP2A) which is upregulated in many malignances. The activity of TOP2A is required for RNA polymerase II transcription on chromatin templates....

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Source

Identifiers

PMID: 18348204
DOI: 10.1002/jcb.21742

Genes

CTCF
IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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