Article
Association of autoimmune pancreatitis with cytotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients.
The American journal of gastroenterology - 1 Mar 2008
Umemura Takeji, Ota Masao, Hamano Hideaki, Katsuyama Yoshihiko, Muraki Takashi, Arakura Norikazu, Kawa Shigeyuki, Kiyosawa Kendo
Abstract excerpt
OBJECTIVES: Autoimmune pancreatitis (AIP) is characterized by high serum IgG4 concentrations, lymphoplasmacytic inflammation, and a favorable response to corticosteroid treatment. Although the HLA DRB1*0405-DQB1*0401 haplotype and Fc receptor-like 3 polymorphisms have been associated with AIP, the role of other genetic factors is largely unknown. As cytotoxic T-lymphocyte antigen 4 (CTLA4) polymorphisms have...
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